Objectives of this project

Fidelity of cell division is highly dependent on the ability of internal cell structure called mitotic spindle to preserve its structural functions and to generate forces under high compressive loading which results in spindles being prone to instabilities and buckling.

Spindle FEA application is designed to employ continuous mechanics principles using the Abaqus CAE finite element code to study buckling of the mitotic spindle as a whole in various phases of mitosis.

Spindle FEA has a modular structure which allows easy modification of any particular part of the analysis which is of particular importance considering that new data on cell division and spindle architecture is constantly emerging.

Thanks to highly optimised finite element solver the application is particularly useful in multi-parameter large-scale modelling.